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Chapter 4: Cytoplasmic Membrane System II, Endocytic pathway, Exocytic @…
Chapter 4: Cytoplasmic Membrane System II
Introduction
Co
Translation Translocation - exterior enter ER
Post
Translation Translocation - interior sent to mitochondria, chloroplasts, peroxisomes, nucleus after translation
Gunter Blobal, 1970 - conducted experiments translocation of protein across membrane
awarded Nobel Prize, 1999
discovered many proteins have signal sequence (short amino acid sequence) at one end of protein that functions like postal code for target organelles
Nascent protein - protein formed by a ribosome before it folds into its active shape.
paths of protein trafficking
:one:
nucleus
(mRNA produced by transcription)
:two:
ribosomes
(cytosol)
:three:
completed
protein via Posttranslational import
cytosol
nucleus
mitochondria
plastids
peroxisomes
:three: ribosomes
partially
synthesized protein (attached to
ER
, via Cotranslational import)
:four:
Golgi Apparatus
via vascular transport
:five: secretory vesicles
:six:
plasma membrane
:five: vesicles from Golgi fuse Early Endosomes :arrow_forward: Late Endosomes
:six: Late Endosomes :arrow_forward: Lysosomes
Biosynthetic @ Exocytic pathway
Endocytic pathway
Exocytic @ biosynthetic pathway