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Micro Section 4 - Coggle Diagram

- - - - Correct
        
        Incubation 2-14 days (~7)
        
        Rocky mountain spotted fever
        
        Vector?
        
        Dermacentor ticks
        
        Correct
        
        1 more item...
        
        Rodent Mites
        
        Vector for what Rickettsial illenss?
        
        2 more items...
        
        Months of increased infection?
        
        April through september
        
        Tick season!
        
        Source of cellular damage?
        
        Direct
        
        Correct
        
        1 more item...
        
        indicrect
        
        incorrect
      - General Rickettsia properties
        
        Gram stain and morphology
        
        Gram negative Rods
        
        LPS Uniquities?
        
        Weakly endotoxic LPS
        
        O2 Requirements?
        
        obligate aerobes
        
        Invade what cells?
        
        Vascular Endothelial Cells
        
        Escape phagolysosome using?
        
        Phospholipase
        
        Cellular Requirements?
        
        Obligate intracellular
        
        Adherence protein?
        
        ompA
      - Clinical Pathology
        
        Leaky BVs
        
        Petechia + edema
        
        This process is?
        
        Fulminant vasculitis!
        
        Occlusion of small vessles
        
        Microthrombi/emboli
        
        Possible DIC (rare)
    - - Causative agent of what infection?
        
        Rickettsialpox
        
        Correct
        
        Urban distribution
        
        2 phases of infection
        
        Phase 1
        
        1 more item...
        
        Phase 2
        
        1 more item...
        
        Epidemic typhus
        
        Cause?
        
        Rickettsia Prowazekii
        
        Correct
        
        Transmission vector?
        
        2 more items...
        
        Rickettsia Typhi
        
        Endemic Typhus
        
        Spreads through tissues how?
        
        2 more items...
  - - - Gram stain?
        
        Gram negative
        
        special fact?
        
        Lack peptidoglycan and LPS
      - 2 morphologic forms?
        
        Elementary bodies and reticulate bodies
      - Cellular requirements
        
        Obligate intracellular
      - Form what in cells?
        
        morulae
      - Prevent phagosome fusion
    - - Hematopoetic cells
        
        Specific cells for anaplasma
        
        granulocyte
        
        Specific cells for ehrlichia
        
        monocyte
    - - Ehrlichia
        
        Lone Star tick
        
        Reservoir
        
        White tail dear
      - anaplasma
        
        Ixodes Tick
        
        Reservoir?
        
        small mammals
    - - Apr-Sept
    - - incubation?
        
        1-3wks
      - symptoms
        
        lu-like illness with fever, headache, myalgia, malaise, and gastrointestinal symptoms (~20%
        cases)
        
        Rash is rare!
      - Hematogenous symptoms
        
        Leukopenia, thrombocytopenia, and elevated serum hepatic transaminases are commonly
        present. Mild anemia may also be present.
      - Detection and treatment
        
        Diagnostic of peripheral blood
        
        Giemsa stain for morula
        
        Diagnostic test
        
        PCR and serology
        
        Treatment?
        
        Doxycycline
  - - - Size of Innoculum necessary?
        
        very small
        
        How are you exposed?
        
        Contaminated fluids and placenta
        
        Route of innoculation?
        
        Inhalation or abrasion
        
        1 more item...
      - 2 Phase antigen
        
        Phase 1: LPS + O
        
        Which is acute which is chronic?
        
        Acute
        
        LPS alone
        
        chronic
        
        LPS with O
        
        Chronic immune complexes contribute to pathogensis
        
        Phase 2: LPS Lipid A ONLY
      - Reservoir for human infection
        
        Cows goats sheep
      - Q fever
        
        incubation
        
        20d
        
        Fever, Chills, Myalgias, Flu-like Symptoms, Gastrointestinal symptoms (nausea, vomiting or
        diarrhea)
        
        Mild to Severe Respiratory Involvement: similar to atypical pneumonia
        
        50% of patients experience hepatosplenomegaly
        
        Chronic
        
        Incubation :Months-Years following exposure
        
        Subacute endocarditis: most common presentation
      - Shape and Gram stain?
        
        Coccobacillus, gram negative
      - Most Infections are Asymptomatic or Mild
      - 2 forms?
        
        SCV and LCV
        
        Internal
        
        LCV
        
        External
        
        SCV
        
        What causes the shift?
        
        fusion with phagolysosome
        
        1 more item...
        
        can disseminate to other organs
      - Detection + treatment
        
        PCR and ELISA
        
        Acute
        
        Phase 2
        
        Chronic
        
        Phase 1
        
        Treat wtih?
        
        Doxycycline
        
        acute!
        
        Chronic treat?
        
        Doxy+HCQ
        
        18mths
      - Cellular reqs
        
        obligate intracellular
  - - - Epidemeology
        
        Peru, ecuador, Colombia
      - Clinical presentation?
        
        Oroya fever
        
        acute febrile illness (headache and myalgia) with severe anemia
      - Pathogenesis
        
        infects erythrocytes
        
        leads to?
        
        anemia
      - Verruga
        
        Peruvian wart
        
        Chronic Cutaneous form
        
        described as?
        
        Angioproliferative
      - vector
        
        Sand fly
    - - Diseases?
        
        Trench fever, 5 day fever
        
        variation in symptoms?
        
        Asymptomatic to severe disease presentations
        
        Recurrent fevers with bacteremia
      - major symptoms?
        
        Malaise, body aches, fatigue, weight loss, headaches and recurrent fever
        
        Can lead to endocarditis
      - Vector?
        
        Human body louse
      - Target audience?
        
        Homeless, Immunocompromised Individuals (HIV/AIDS)
    - - Fastidious req?
        
        CO2
        
        also is slow
      - Incubation?
        
        1-6wks
      - O2 usage?
        
        obligate aerobe
      - Agar?
        
        blood agar
      - Gram stain?
        
        negative
    - - clinical pres
        
        Papule appears at innoculation the site and Lymphadenopathy of regional lymph nodes
      - occurs in
        
        Can occur in Immuncompetent Adults but is more common in Children
      - Vector
        
        cat flea
        
        reservoir
        
        cats
      - Immunocompromised differeces?
        
        Bacillary Angiomatosis
        
        this is?
        
        Vaso-proliferative disease
        
        causes
        
        Cutaneous lesions become blood filled
        
        1 more item...
      - AKA
        
        Cat scratch fever
      - Detection
        
        serology and skin biopsy
        
        immuno comp
        
        Bacteria seen in Lymph nodes but culture negative
        
        immuno compromised
        
        Chronic bacteremia – culture from blood
      - Treat
        
        macrolides of doxy