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DNA REPLICATION - Coggle Diagram
DNA REPLICATION
Requirements
Primers
RNA (10 nucleotides)
RNA primase
enzyme 4 primer synthesis
DNA template
DNA double helix→single strand
DNA protein
DNAHelicase
SSBs (single stranded binding protein)
DnaA protein
DNA topoisomerases
Substrates
dTTP
dCTP
dATP
dGTP
DNA polymerases
DNA polymerase II
proof reading & repair enzyme
DNA polymerase I
●Fill small gap during replication & repair.
●Remove RNA primer by exonuclease activity
●Proofreading
DNA polymerase III holoenzyme
4 DNA synthesis
Characteristic
Bidirectional
replication starts from origin
&proceeds in 2 opposite direction
High fidelity
high accuracy
Semi-conservative replication
half of parental DNA conserved
-then paired w newly synthesized strand
Semi continuous
one strand synthesized continously
other strand discontinues
1.Initiation
2.Elongation
3.Termination :