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Purple Team
What occurs on a cellular level when DNA vaccines enter the body? What is the end result?
After the DNA vaccine is injected into
the body, it accomplishes two goals
creating a
strong cellular response
building a potent
humoral, or antibody, response
when DNA vaccines enter the body on a cellular level
DNA vaccinations prompt helper T cells and B cells to multiply and produce memory cells, as well as activate cytotoxic “killer” T cells
This type of dual cellular and humoral response gives long-lasting immunity, similar to what most live attenuated vaccines achieve
the end result
DNA vaccines that target a pathogen, as well as therapeutic vaccinations, which fight cancer.
What is one reason why DNA vaccines remain in clinical trials?
In clinical trials with human patients, DNA vaccines have shown mixed results.
It is associated with the ability to disrupt cellular processes and generate anti-DNA antibodies, resulting in low levels of immunogenicity.
Not effective enough.
When did DNA vaccines first begin being developed? Are they widely available today?
the vast majority
of DNA vaccines are still in clinical trials
DNA Vaccines first begin being developed in 1990s
why are DNA vaccines considered safer than attenuated vaccines?
there is no risk that they may
cause an illness
How are DNA vaccines created?
scientists first isolate a gene from the target pathogen. They then splice the viral gene into a double-stranded DNA vector