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Amyloid Precursor Protein (APP), embedded in cell membrane, Glycoproteins …
Amyloid Precursor Protein (APP)
alpha-secretase
ADAM's
ADAM-9
ADAM-10
TACE
Beta-secretase
BACE1 (aspartyl protease)
Amyloidogenic pathway
APPsB
C99
AICD
Non-amyloidogenic pathway
APPsA
C86
AICD
y (gamma)-secretase
Nicastrin (involved in peptide amyloid Beta)
AB
P3
Alpha-cleavage
Beta-cleavage
gamma-cleavage
embedded in cell membrane
Glycoproteins
