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Tissue and Organs in Health & Disease, Cross-species comperison,…
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Cross-species comperison
Embrionic organoids:
What are the advanteges and cons?mouse - 20 days
human - 60 days-mimik embrio life structures
- mimik from 1 til day 10
human - til 1 month
What are the transitional stages during development?
ETX organoids mimick implantation stage
Do they hit puberty at the same time? or different?Each stage is mimik separatlyPros and cons of organoids? not really reproducible
less robust, don't have to take animals, organoids affected by inicial cellsAdvantages:
- inaccessible species
-disease
-throughput (drug screening)
-imaging
-no animal experiments
Dis:
-low reproducibility
-artifacts (like lumen)
-immaturity (without blood vessels)
-costs
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Gestation - pregnancy period
What is the signal to begin oscillation?
Coctail of factors, is there number of cell dependacy?
Human - slower biochemical reaction
manipulate the time of development - big goal
Disease organoids:
somites - formation of 1 pair of somites
Resquid organoids showed regular oscillation
identify novel desease genes with organoids!
What type of research people do?
-screening
-describing properties
-changing properties
-applying new technologies
What to do with minor defects? out of organoids system
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