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DNA Replication - Coggle Diagram
DNA Replication
Steps
Synthesis of Leading Strand
DNA is opened
DNA is unwound and primed
Primase
synthesizes Primer
Topoisomerase
relieves twisting forces
Helicase
opens double helix
ssDNA BPS
stabilizes single strands
Synthesis of leading strand begins
DNA Polymerase
synthesizing leading strands in 5' --> 3' direction
Sliding camp
holds DNA Polymerase in place
Synthesis of Lagging Strand
Primer is added
Primase synthesizes RNA Primer
First fragment is synthesized
DNA polymerase 3 works in 5' to 3' direction
synthesizes 1st okazaki fragment of lagging strand
Second fragment is synthesized
Primase and DNA Polymerase 3 synthesizes another okazaki fragment
Primer is replaced
DNA Polymerase 1
Removes ribonucleotides of primer
replaces them with deoxyribonucleotides in 5' to 3' direction
Gap is closed
DNA Ligase closes gap in sugar-phosphate backbone
synthesized away from the replication fork
Replisome
DNA synthesizing machine
Repair
Synthesis Errors
DNA Polymerase 3 proofreads
Exonuclease Activity
Mismatch Pair
Post proof reading
Mutation correlated with cancer
Damage Errors
Genes
Made up of DNA
Only the genes can enter the host cells
Production of new virus particles
directed by virus genes
End of Infection
New generation of virus particles bursts from host cells
Start of Infection
Virus genes enter a host cell. Capsid does not
Mechanism
Replication is semiconservative
Separation of 2 parental strands
Directionalities