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Urinary Tract Infections - Coggle Diagram

- - - - GI intolerance
      - neuropathies
      - pulmonary reactions
    - - 100 mg BID for 4-7 days
    - - Half-life
        
        20-60 minutes; prolonged with renal impairment
      - Elimination
        
        Suspension: Urine (40%) and feces (small amounts) as metabolites and unchanged drug
        
        Macrocyrstals: Urine (20% to 25% as unchanged drug)
      - Absorption
        
        well absorbed; macrocyrstalline absorbed more slowly due to slower dissolution
        
        Bioavailability is increased with food by 40%
      - Metabolism
        
        Body tissues (except plasma) metabolize 60% of drug to inactive metabolites
      - Distribution
        
        Vd 0.8 L/kg
        
        Protein binding: 60-90%
    - - BCG (Intravesical), BCG Vaccine, Cholera Vaccine, Dapsone (topical), eplerenone, Lactobacillus and Estiol, local anesthetics, magnesium trisilicate, nitric oxide, norfloxacin, priolcaine, probenecid, sodium nitraite, sodium picosulfate, typhoid vaccine
  - - - aminolevulinic acid (systemic), BCG (intravesical), cholera vaccine, dofetilide, leucvorin calcium-levoleucovorin, mecamyline, methenamine, metronidazole (systemic), Potassium P-Aminobenzoate, procaine, Secnidazole,
    - - One 800mg/160 mg tablet PO BID for 3 days (females) or 7 days (males)
    - - Rash
      - SJS
      - Renal failure
      - photosensitivity
    - - Half-life
        
        Adults 6-11 hours
      - Absorption
        
        Rapid; almost completely (90-100%)
        
        Time to peak 1-4h
      - Distribution
        
        distributes to middle ear fluid, sputum, and vaginal fluid. TMP distributes to bronchial secretions
        
        Vd for TMP: adults ~1.3 L/kg
        
        Protein binding - SMX ~70%, TMP ~44%
      - Elimination
        
        excreted in the urine as metabolites and unchagned drug
      - Metabolism
        
        hepatic to multiple metabolites. SMX to hydroxy (CYP2C9( and acetyl derivatives and conjugated with glucuronide. TMP to oxide and hydroxy derivatives
- - - - SGLT2 inhibitors