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Lupus - Coggle Diagram
Lupus
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PATHOGENESIS
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The disease has autoantibodies against nucleic acids, erythrocytes, coagulation proteins, phospholipids, lymphocytes, and platelets. (3)
There is a deposition of circulating immune complexes that contain antibodies against the host's DNA. (3)
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Simply, lupus is a total loss of self-tolerance with activation of auto-reactive T and B cells leading to the production of pathogenic autoantibodies and tissue injury. (4)
WORKS CITED
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- Online textbook: Understanding Pathophysiology, 7th Edition, by Sue E. Huether, Kathryn L. McCance, and Valentina L. Brasher
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DIAGNOSIS
Laboratory tests include: complete blood count, erythrocyte sedimentation rate, kidney and liver assessment, urinalysis, and ANA test (1)
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RISK FACTORS
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Race: Lupus is more common in African Americans, Asian Americans, and Hispanics
TREATMENTS
Medications included can be: NSAIDS, corticosteroids, antimalarial drugs, BLyS-specific inhibitors, and immunosuppressants (2)
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CLINICAL MANIFESTATIONS
Individuals may go through periods of remission and be relatively disease free until the onset of a "flare".
Symptoms include:
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Hematologic changes, especially anemia (50%)
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Common clinical findings
Rash, photosensitivity, arthritis, serositis, renal dysfunction, neurological disorders, and hematologic manifestations (When they all occur together it is highly suggestive of SLE)