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cop-1 and p53 - Coggle Diagram
cop-1 and p53
experimental error
too much heat shock (burns through the protein)
cross contanimation
the opposite: not enough of heat/oxygen removal
extraction/insertion of mRNA doesn't work
IR does not work (dna isn't damaged)
environment is too "stressful" or 8 weeks is too long
stress factors that make activate p53
hypoxia
dna mutation
spindle damage
heat/cold shock
tumor creation
cell cycle has an error
dna can get replicated incorrectly
chromatids may not be pulled apart correctly
checkpoints to check how the process if going which is when p53 comes in
what is p53
tumor surpressor
will show up at cell cycle checkpoints to check for errors
each stress signal causes a different regulation pathway
what is cop-1
negative regulator of p53
attaches ubiquitin to target protein for degradation
ubiquitin E3 ligase (ring finger containing protein)
cop-1 in tumors
higher expression in order to remove p53
higher expression has only been found in ovarian and breast cancer