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Asthma - Coggle Diagram

- - - - Severe hypersensitivity to milk proteins
      - Increased incidence of secondary infection with prolonged use
      - Adrenal suppression: may cause hypercortisolism
    - - CYP3A4 Inhibitors can increase concentrations of budesonide
    - - Safety and efficacy in pediatric <6 YO has not been established
    - - Income status may affect adherence to medications, also effecting children.
- - - - CD4+ cells, eosinophils, basophils, neutrophils, and macrophages are recruited
      - CD4+ cells release Th2-related cytokines --> late-phase reaction occurs
      - Cytokines are released by mast cells after initial exposure to environmental trigger
    - - Inflammation in airways
        
        Increased mucus secretion by epithelial cells of the airways
        
        Smooth muscle bronchospasm
        
        Vasculature of airways becomes leakier --> edema, reduced clearance of mucus, and formation of exudative plugs
      - Acute airflow obstruction
      - Activation of mast cells and macrophages and release of inflammatory mediators (like histamine)
      - Activation of cells w/ IgE