PATHOLOGY—Inflammation and Neoplasia

Scar formation

Hypertrophic

Keloid

Neoplasia and
neoplastic progression

Normal cells

Dysplasia

Carcinoma in situ/
preinvasive

Invasive carcinoma

Metastasis

Tumor nomenclature

Tumor grade vs stage

Hallmarks of cancer

Growth signal
self-sufficiency

Anti-growth signal
insensitivity

Evasion of apoptosis

Limitless replicative
potential

Sustained
angiogenesis

Tissue invasion

Metastasis

Warburg effect

Immune evasion in
cancer

Cancer epidemiology

Immune checkpoint
interactions

Cancer incidence men,women kids

Cancer mortality

Common site of metastases

Brain

Liver

Bone

oncogenes

ALK

BCR-ABL

BCL-2

BRAF

c-KIT

c-MYC

HER2/neu (c-erbB2)

JAK2

KRAS

MYCL1

N-myc (MYCN

RET

Tumor suppressor
genes

APC

BRCA1/BRCA2

CDKN2A

DCC

SMAD4 (DPC4)

MEN1

NF1

NF2

PTEN

Rb

TP53

TSC1

TSC2

VHL

WT1

Carcinogens

Aflatoxins (Aspergillus)

Alkylating agents

Aromatic amines

Arsenic

Asbestos

Cigarette smoke