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Anticancer Agents(Antineoplastic agents) - Coggle Diagram
Anticancer Agents(Antineoplastic agents)
according to Site of action:
Influence hormone homeostasis
Hormones
Biological Response Modifiers (BRM)
cytokines
antibodies
Immunotoxins
Enzymes
Protein tyrosine kinase inhibitors
Miscillaneous
Tretinoin
arsenic dioxide
thalidomide
bexarotene
bortezomib
Mitosis
Mitotic inhibitors
Topoisomerase inhibitors
Receptor sites (targeting)
antibodies
Interfere protein synthesis and function
Antimetabolites
Alkylating agents
according to cell cycle:
Cell Cycle Specific Drugs
Asparaginase (G1& S)
Bleomycin (G2)
Mitotic Inhibitors (M)
Etoposide (G2)
Anti-metabolites (S)
2-Pyrimidime deriv.
5-Fluorouracil (5-FU)
Indications:
FOLFOX regimen: Folic acid, 5FU and oxaliplatin
3- Purine deriv.
1- Antifolates
Methotrexate (Folex)
Other derivatives
Permetrexed
Pralatrexate
[Indication:]
Maintenance therapy for childhood acute lymphoplastic leukaemia POMP
Oncovin
MTX
Prednisone
Purinethol
Antidote
Leucovorin /Folinic acid/ Citrovorum factor
NEW Derivatives under clinical trials against cancer
Trimetrexate
Edatrexate
Piritrexim
Tomudex
Lometrexol
Cell Cycle Nonspecific Drugs
Alkylating Agents
Most antitumor antibiotics