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7.4: Tired and Itchy, Medium/long term management, Short term management,…

- - - - Viral envelope fuses with membrane of endosome and nucleocapsid is released into cytoplasm
        
        HBV partially double stranded DNA translocates to the nucleus, where host enzymes repair it to form covalently closed circular DNA, which is a template for the transcription of 4 mRNAs
        
        3 mRNAs encode structural proteins and other components of the virion, and travel to rER to be translated by host ribosomes
        
        Proteins and DNA are packaged into a new virion, which is released from the hepatocyte
        
        Period of immune tolerance with high HBV DNA, as well as positive HBsAg and HBcAg, but no liver damage
        
        In immune clearance, immune response decreases HBV DNA (fluctuantly) with positive HBsAg and HBcAg and liver damage
        
        3 more items...
        
        Hepatocellular accumulation of HBsAg
        
        1 more item...
        
        1 mRNA is pregnomic RNA, which travels to the cytoplasm and becomes encaspulated in the capsid then converted to DNA by reverse transcriptase
        
        Nucleocapsid is recycled and translocates back to the nucleus (reservoir of HBV)
        
        Nucleos(t)ide analogues: entecavir and tenofovir
      - Pegylated interferon