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Quantitative, non-invasive CSF pressure measurement (Brainstorm #2) -…
Quantitative, non-invasive CSF pressure measurement (Brainstorm #2)
Radical innovation
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Sticker/patch on the back of patient's neck that detects minor changes in patient's everyday movement resulting from abnormal CSF pressure
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Reporter microorganisms that are designed to release a biomarker or emit fluorescence upon recognition of high CSF amounts in the CNS
Spinal implant that expands in the context of more fluid, shrinks back when CSF amount is normal. Can image this implant whenever pressure measurement is needed
Moderate innovation
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Algorithm that reads in an image of a retinal scan and quantifies pressure in the eye, then correlates it with CSF pressure
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Moonshot innovation
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Sinus venous drainage drains into reservoir in the spine. Amount of CSF accumulated is measured and reported by device.
Surgically insert a CSF pressure modulator in the vertebrae. Expels or takes in CSF based on real-time measurement of fluid amount
Wearable belt that measures stiffness of spine, which may increase with CSF overload
Technology exists, expanding application
Ear tubes are currently used for drainage from the middle ear. Since CSF leakage from high pressure or physical tear sometimes occurs through the ear, could ear tubes be adapted to collect/measure CSF?
EEG (used to detect abnormal brain waves) could be made more sensitive to detect changes in CSF pressure or turbulent fluid flow in the intracranial region.
Take arterial blood pressure measurement (this tech exists). Statistical analysis/ML to establish predictive model of CSF pressure based on arterial BP.
Biological discovery
Since many migraines are hormone induced and IIH may also have a hormonal pathophysiology (strongly indicated, as IIH mainly occurs in women of child-bearing age), could hormone levels be a marker for CSF pressure?
Identify biomarkers associated with high/low CSF pressure through a large-scale proteomics or transcriptomics study
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