Please enable JavaScript.

Coggle requires JavaScript to display documents.

Filter Failure, used to, include, include, include, can cause, lead to,…

- - - - Overproduction of ROS
        
        oxidative stress
        
        Production of TGF-B
        
        mesangial cell proliferation
        
        Kimmelstiel-Wilson lesions
    - - Increased permeability of vessels to fibrinogen
        
        Fibrinoid necrosis
        
        Kidneys become ischemic
        
        RAAS activation
        
        Worsen hypertension
      - Endothelial injury and platelet deposition
        
        Intimal hyperplasia
        
        Hyperplastic arteriosclerosis
  - - - Protienuria
    - - Scaring
      - Fibrosis
    - - Normocytic anemia
    - - <60ml/min/1.73m2
    - - Electrolyte imbalance
  - - - Anemia
  - - - Control diabetes
      - Control hypertension
    - - Dialysis
        
        Hemodialysis
        
        Peritoneal dialysis
      - Kidney transplant
- - - - Should benefit the receiver with no harm to donor
      - Not affect the rights of donor's spouse, children and other family members
      - Donation of organ is permitted but restricted
- - - - Complete and irreversible stop of vital functions
    - - Death of tissues and cells
      - Happens 1 to 2 hours after somatic death
- - - - one location to another from the same body
    - - genetically identical donor
    - - genetically different donor
    - - different spices
  - - - type II hypersensitivity
      - minutes to hours
      - Capillary thrombosis
    - - Types IV hypersensitivity
      - weeks to months
      - lymphatic infiltrates
    - - Types II and IV hypersensitivity
      - months to years
      - Interstitial fibrosis
- - - - Prevent & treat rejection
    - - Alemtuzumab
      - Rituximab
      - Basiliximab
        
        Bind to IL-2 receptor
        
        Proliferation inhibition
  - - - inhibition of nucleic acid synthesis
      - Azathioprine – Mycophenolate
      - GI symptoms
    - - Cyclosporine – Tacrolimus
      - Nephrotoxicity - infections