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Muscular System, Ilyanna Sanchez, Period 1 - Coggle Diagram
Muscular System, Ilyanna Sanchez, Period 1
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Neuromuscular junction
- Axons travel from central nervous system to skeletal muscle
- Axon branches end on muscle fiber, forming neuromuscular junction
▪ Muscle fiber has one neuromuscular junction with one motor neuron
- Neuromuscular junction consists of axon terminals, synaptic cleft, and junctional folds
- One of the steps that occur for the skeletal muscle to contract
- Many toxins, drugs, and diseases interfere with events at the neuromuscular junction
Events
- AP arrives at axon terminal
- Voltage-gated calcium channels open, calcium enters motor neuron
- Calcium entry causes release of ACh neurotransmitter into synpatic cleft
- ACh diffuses across to ACh receptors on sarcolemma
- ACh binding to receptors, opens gates, allowing 𝑁𝑎 +
to enter resulting in end plate potential
- Acetylcholinesterase degrades ACh
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Muscle coverings
- Epimysium: dense irregular connective tissue surrounding entire muscle; may blend with fascia
- Perimysium: fibrous connective tissue surrounding fascicles
- Endomysium: fine areolar connective tissue surrounding each muscle fiber