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GBS Brainstorm Concept Tree - Coggle Diagram
GBS Brainstorm Concept Tree
Diagnostics
Imaging
Phone Camera Attachment
Measuring changes in absorbance/ transmittance
Using lasers/ spectroscopy
Live imaging flora in vagina/ rectum
Way to identify GBS through microscope image
ML algorithm to analyze microscope image (integration with foldscope?)
With stain for GBS
Without stain for GBS
Biochemical
Cervical wipe that can be mailed to patient
At-home molecular test that can be analyzed by your phone
CRISPR-CAS system (binds to DNA/RNA of from GBS cells, non-specifically cuts quenched reporters, similar to mamouth biosciences COVID test)
RT-LAMP test that identifies marker RNA for GBS
At-home urine dipstick test
Nanobodies via dipstick
Stool detection of the GBS bacteria
Monitor sewage for prevalence of GBS
Lab box that runs full GBS culture to results
In the clinic
At-home
Augmenting GBS-related behavior
Induce Artificial Immune Response in the mother
Speed up growth of bacteria to increase detection speed
A pregnancy-style screening tool for GBS (Lateral Flow Assay)
Lateral flow assay with lysing step to allow for targeting of a protein inside GBS cells
Lateral flow assay targeting surface protein of GBS
Lateral flow assay for GBS without amplification of the target/antigen
Later flow assay for GBS with amplification of the target/antigen
At-home color-changing swab test
Wipe
Swab
Analyze biofilm changes
Public Health/ Education
Public Health
Traveling/ Pop-up Clinic
Doctors Without Borders
Habitat for Humanity
Complimentary Consulting Service to Accompany Testing
Government Policies
Convince government to adopt texting
Allocation of More Resources
Convince hospitals to adopt testing
Education
Ad Campaign for Screening
WhatApp/ Text Campaign
Facebook Ad
Fundraiser to build labs and hospitals
Education teams conduct workshops
Better models of vaginal GBS flora from conception -> delivery
Familial Outreach
Increased screening
screen partner for GBS
screen previous children for GBS
family network that connects families
information campaign for partners of pregnant women
outreach at grocery stores
household-level testing
family waste tracking system
testing household sewage system
cross-referencing of familial health record via platform
Financial/ Economic
Financial incentives for testing
Cheaper Equipment for Testing
cost of lab equipment
cheaper PCR machine
cheaper cell incubator system
cheaper enriched medium
cost of test
cheaper material
cheaper reagent
engineer cells to make requisite material
Digital Solutions
Wearables
Smart Tampon to monitor GBS
smart menstrual cup
smart pad
Wearable sensors that analyze biometric data
Temperature sensor
pH sensor
Electroconductivity changes
implantable device for tracking vaginal/ rectum mircobiome
real-time, persistent detection of GBS in birth canal
App for improving access to GBS-related care
App helping pregnant women find/get to nearest antenatal care clinic
App and tools for end-to-end, self-administered, at-home antenatal care
Virtual education sessions on GBS and other antenatal care
Smart Toilet to detect GBS in stool
Telehealth consult with physicians for testing
robotics
Nanobots in food source of entire nation to scan for GBS as they pass through digestive tract and rectum
mini-bot like those for colonoscopy to detect GBS
Risk Assessment
Standardized protocol for identifying patients at risk for GBS infection
Machine learning algorithm
hospital-wide tracking of GBS to find regional risk factors
population-wide study/model that predicts areas where people are particularly at risk
searches health records for risk assessment
genetic screen for GBS risk
wearable that tracks biometrics to find potential risk factors
Standardized questionnaire for identifying GBS risk factors
incorporate risk assessment data from partners and other family members
Using phone data to assign risk scores for GBS
upload vaginal images to phone to assess risk