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Distribution - Coggle Diagram
Distribution
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Volume of distribution
- Formula: Vd = dose administered / dose at plasma concentration
- Larger Vd = drug found in tissues
- Smaller Vd = drug confined in circulatory system
Total body water (TBW) = 0.6 x body weight
- Vd higher than TBW = drug highly distributed into tissue
- movement of drug from the systemic circulation to the site of drug action (interstitial fluid/cells of the tissues)
- drug moves until there is euqilibration between unbound drug in plasma and tissue fluids