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PHARMACOLOGY | Drug Metabolism - Coggle Diagram
PHARMACOLOGY | Drug Metabolism
Alteration of drug structure into drug metabolites to be excreted
Most drugs or xenobiotics transform into hydrophilic metabolites
Protect body from toxic metabolites
Pathways of metabolism
Oxidation
Conjugation
Results of Biotransformation
Inactive metabolites
Active product
Active drug from prodrug
Toxic metabolites
Organs involved in drugs metabolism
Liver (main)
Kidney
Muscle tissue
Intestinal wall
Lungs
Skin
Blood
Phase of biotransformation
Phase I: Become polar metabolites and loss of pharmacological activity
Phase II: Conjugation reaction (true detoxification of drugs)
Drug metabolism can be induced or inhibit