"The upset of doing business is much worse then the actual business in the home office, and, besides, I've got the torture of traveling, worrying about changing trains, eating miserable food at all hours, constantly seeing new faces, no relationships that last or get more intimate (4)."
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Before Gregor's sudden Metamorphosis he was still consistently alone having to travel from place to place with no rest by his boss.
He was given no chance to form deep and long lasting relationships which led him to grow depressed as the days went by. Gregor solely became a worker with no emotional ties to other people.
