Using different kinds of antibiotics treatment will have different benefits and limitations. For example, azithromycin is a good antibiotic to use but at the same time, it may cost allergic reactions, severe skin reactions, severe diarrhea, liver damage, and heart arrhythmias. Another example of this is doxycycline, doxycycline is widely used to kill bacteria in your body but the downside is that it costs headache, nausea, dyspepsia, joint and back pain, nasal and sinus congestion, or a rash.