Can begin at 6-8 weeks of age (nursery) and into the grower phase (~20 wks). Low morbitity but high case fatality. VARIABLE clinical signs: poor growth, weight loss, anemia, pallor, wasting, emaciation, dyspnea, lymphadenomegaly, jaundice (terminal), diarrhea (growers), splenomegaly, chronic interstitial nephritis.