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Huntington Disease - Coggle Diagram

- - - - Gene codes for production of a protein called Huntingtin
        
        Function is still unknown
      - Defected version of the gene has excessive repeats of a three-base sequence “CAG”
      - Normal gene sequence repeats between 11 and 29 times
      - Mutated gene repeat occurs over and over again, from 40 times to more than 80
        
        Defect causes the resulting of the huntingtin protein to be malformed
        
        Prone to clumping in the brain and causing death of nearby nerve cells
        
        Cells of the basal ganglia, a brain responsible for coordinating movement, and the cortex, which controls thought perception and memory, are all most often affected