Lactogenic antibodies are crucial - agalactia -> E. coli diarrhea. Adherence to SI epithelium via F4, F5, F6,F41 fimbrial adhesins. Colonization of jejunal/ileal mucosa. Enterotoxins (STa, STb, LT) -> secretory diarrhea and ALKALINE feces. Pathology unrewarding (non-specific, mild) - dilated fluid-filled SI, congestion of SI vasculature, dilated stomach with infarcts along greater curvature, dehydration.