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Friendship and Natural Selection - Coggle Diagram
Friendship and Natural Selection
Christakis NA, Fowler JH. 2014. Friendship and natural selection. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1400825111.
Four reasons possible for friendship selection(not mutually exclusive)
choose friends with same genotype
choose friends with same phenotype which might lead to same genotype
choose certian enviorments which may lead to meeting people with same genotype
tend to make friends with those with similar ancestory
Choose by others into enviorments where more likely to meet people with same genotype
Experiment
Used genome-wide association study(GWAS)
Data utilized from Framingham Heart Study
split sample replication used to check against false positives
Positive values measured indicate relatedness
Negative values indicate two are not related
For comparision also calculated strangers pairs
Intrested in whole genotype not just SNP
Discussion
Friends have kinship coefficient of fourth cousins
Friends have similar genotype for sense of smell
CMS suggest that increase in homophilic SNP frequency has been due to recent selection
Composite of Multiple Signals score used to test if SNP under recent selection
Conclusion
Humans metagenomic with respect to friends
Recent human evolution driven by homophilic genotypes
Friends tend to have more in common genotype than that of strangers