Please enable JavaScript.

Coggle requires JavaScript to display documents.

Respiratory block - Coggle Diagram

- - - - Standardisation for age, sex, ethnicity and height
- - - - (upper airway)
      - airway regeneration
      - differentiate into all airway epithelial cells
    - - able to give rise to airway and alveoli cells in vivo
    - - type 2
        
        increase rate of proliferation and differentiation to replace both cell type
        
        main stem cell in the alveoli
      - Type 1
        
        gas exchange
  - - - resected from cancer or pathogenesis
    - - some process in development used in repair mechanism
- - - - M > F; Smokers, Occupational, Mutation
    - - • Multi-focal diffuse parenchymal lung disease within the alveolar
        Fibrosis --> Thickening of interstitium
    - - Exclusion of other ILD + Radiology UIP pattern in HR-CT + Pathology (Honeycombing, opacities)
    - - Furin inhibitor
      - Tyrosine kinase inhibitor
      - Lung transplantation
      - O2 therapy
  - - - Bronchiolitis
      - Chronic bronchitis
      - Emphysema
    - - Reversible
        
        Cilia paralysed, Reduce mucus clearance, Reduced antioxidant
        
        Infection: Reduced efferocytosis & Catabasis
      - Irreversible: Dys-homeostasis, Pneumonia, CA(Esp. Lung)
    - - Bronchodilators
        
        LAMA
        
        LABA
        
        Methylxanthines
        
        Selective PDE4 blocker
      - Steroids (For eosinophilic inflammation)
      - Anti-eosinophilic Ab?
    - - Type A: Viral/Bacterial
      - Type B: Eosinophilic
      - Type C: Air pollution
      - Type D: Non-inflam, Non-pulmonary
- - - - Spike protein binding to ACE2 receptors
    - - Moderna, Pfizer, JnJ, AZ
  - - - Monitor, Protect
        
        Smoke free policies
        
        Rely on justification that smoking can also
        be injurious to other people
      - Offer help
      - Warn
        
        Mass media campaigns
      - Enforce bans
        
        for advertising of cigarettes
      - Raise taxes or prices
    - - Lung cancers
        
        Tuberculosis
        
        COPD