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Rheumatoid Arthritis - Coggle Diagram
Rheumatoid Arthritis
Treatment
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DMARDs
Methotrexate
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Counseling
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Side effects can include nausea, headache, abdominal pain
Interactions
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Soda
Concurrent use of METHOTREXATE and "COLA" may result in increased methotrexate serum levels and increased risk of toxicity.
Adverse Reactions
diarrhea, N/V, increased liver enzymes
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MOA
folate antimetabolite that inhibits DNA synthesis, repair, and cellular replication; exact mechanism for RA unknown
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TNF inhibitor biologics
Adalimumab
MOA
Binds to TNF alpha and interferes with subsequent TNF alpha binding and cytokine driven inflammatory processes.
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Clinical Presentation
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systemic symptoms: generalized aching, weight loss, depression, fatigue
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Etiology/Pathophysiology
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infiltration of immune cells into the articular space, and development of panus tissue leading to erosion of bone and joint damage