Chapter 2: Neuroscience: The Biologicals Perspective

Interaction of the brain and nervous system

Central nervous system: organize and analyze the information obtained from sensory organs

Peripheral nervous system: Transmit sensory information to the central nervous system and pass out impulses to the effector organ

Brain image

Spinal cord image

Autonomic: involuntary control of internal organs, blood vessels, and smooth and cardiac muscles

Somatic: has voluntary control of our movements via skeletal muscle

The organ located within the skull that is responsible for cognition, mental processes, and control of the body and its functions. It is the location of perception, ideas, thoughts, conscious movement, and unconscious body functions like heart rate and digestion

The cylindrical bundle of nerve fibers and associated tissue is enclosed in the spine and connects nearly all parts of the body to the brain, with which it forms the central nervous system.

Interaction between the brain and spinal cord

Cells of nervous system

Neuron:
specialized cells that transmit chemical and electrical signals to facilitate communication between the brain and the body

Neuroglia cells:
Non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the central (CNS) and peripheral nervous systems (PNS )

Motor neuron (efferent neuron):
a neuron that carries messages from the
central nervous system to the muscles of the body.

Interneuron: A neuron found in the center of the spinal cord that receives information from the sensory neurons and sends commands to the muscles through the motor neurons

sensory neurons(afferent neuron):
a neuron that carries information from the senses to the central nervous system

image

image

image

Neuroglia cells of CNS

Neuroglia cells of PNS

Astrocytes:
✅ they support and brace the neurons and anchor them to their nutrient supply lines.
✅ play an important role in making exchanges between capillaries and neurons.
✅ regulate the external chemical environment of neurons by removing excess ions and recycling neurotransmitters released during synaptic transmission.

Microglial cells:
✅ can transform into a special type of macrophage that can clear up the neuronal debris.
✅ They are also able to monitor the health of neurons by detecting injuries to the neuron.

Ependymal cells:
✅ Line the ventricles of the CNS, forming a permeable barrier between the cerebrospinal fluid (CSF) and underlying cells
✅ Aid in the circulation of CSF through cilial beat

Oligodendrocytes: ✅ They line up along the nerve fibers in the CNS and wrap their process tightly around the fibers producing the insulating myelin sheath

Schwann cells: ✅ Providing myelination to axons in the PNS. ✅ They also have phagocytotic activity and clear cellular debris that allows for regrowth of PNS neurons

Satellite cells: ✅ surround neurons’ sensory ganglia in the ANS ✅ assist in regulating the external chemical environment
✅ very sensitive to injury and may exacerbate pathological pain.

image

image

image

image

image

image

Parasympathetic: Involved in maintaining homeostasis and also, permits the rest and digest response.

Sympathetic: Involved in the fight or flight response

Example:
1)Food digestion
2) Dilates blood vessels leading to the GI tract, increasing blood flow.
3)Constricts the bronchial diameter when the need for oxygen has diminished.
4)Causes constriction of the pupil and contraction of the ciliary muscle to the lens, allowing for closer vision.
5)Stimulates salivary gland secretion, and accelerates peristalsis.
6)Stimulates sexual arousal.

Example:
1)Slamming on the brakes when the car in front of you suddenly stops.
2)Inhibits digestion.
3)Diverts blood flow away from the gastro-intestinal (GI) tract and skin via vasoconstriction.
4)Blood flow to skeletal muscles and the lungs is enhanced (by as much as 1,200% in the case of skeletal muscles).
5)Dilates bronchioles of the lung, which allows for greater alveolar oxygen exchange.
6)Increases heart rate and the contractility of cardiac cells (myocytes), thereby providing a mechanism for the enhanced blood flow to skeletal muscles.
7)Dilates pupils and relaxes the ciliary muscle to the lens, allowing more light to enter the eye and far vision.
8)Provides vasodilation for the coronary vessels of the heart.
9)Constricts all the intestinal sphincters and the urinary sphincter.
10)Inhibits peristalsis.
11)Stimulates orgasm.

Sensory neurons(afferent neurons): responsible for carrying information from the body to the CNS

Motor neurons(efferent neurons): responsible for carrying information from the brain and spinal cord to muscle fibers throughout the body

image

image

Parts of cortex controlling senses and movement

Cerebral Hemispheres

Lobes of the Brain

Corpus callosum - thick band of neurons that connects the right and left cerebral hemispheres.
Cerebral hemispheres - the two sections of the cortex on the left and right sides of the brain.

Occipital lobe

  • section of the brain located at the rear and bottom of each cerebral hemisphere containing the visual centers of the brain.

Primary visual cortex

  • processes visual information from the eyes.

Visual association cortex

  • identifies and makes sense of visual information.

Parietal lobes

  • sections of the brain located at the top and back of each cerebral hemisphere containing the centers for touch, taste, and temperature sensations.

Somatosensory cortex

  • area of neurons running down the front of the parietal lobes responsible for processing information from the skin and internal body receptors for touch, temperature, body position, and possibly taste.

Temporal lobes

  • areas of the cortex located just behind the temples containing the neurons responsible for the sense of hearing and meaningful speech.

Primary auditory cortex

  • processes auditory information from the ears.

Auditory association cortex

  • identifies and makes sense of auditory information.

Frontal lobes

  • areas of the cortex located in the front and top of the brain, responsible for higher mental processes and decision making as well as the production of fluent speech.

Motor cortex

  • section of the frontal lobe located at the back, responsible for sending motor commands to the muscles of the somatic nervous system.

image

Parts of cortex responsible for higher forms of thought

Association Areas of Cortex
• areas within each lobe of the cortex responsible for the coordination and interpretation of information, as well as higher mental processing.

Broca area

  • lies specifically in the third frontal convolution, just anterior to the face area of the motor cortex and just above the Sylvian fissure.
  • It is made up of two areas: the pars triangularis (Brodmann area 45) and the pars opercularis (Brodmann area 44).


  • The Broca area is connected to other regions of the brain, including the Wernicke area, by a neuronal tract known as the arcuate fasciculus.


  • In addition to serving a role in speech production, the Broca area also is involved in language comprehension, in motor-related activities associated with hand movements, and in sensorimotor learning and integration.

Broca’s aphasia

  • condition resulting from damage to Broca’s area (usually in left frontal lobe), causing the affected person to be unable to speak fluently, to mispronounce words, and to speak haltingly.

wernicke’s area

  • This localization of brain function suggests that certain abilities, such as producing and understanding language, are controlled by certain parts of the brain.

Wernicke’s aphasia

  • condition resulting from damage to Wernicke’s area (usually in left temporal lobe), causing the affected person to be unable to understand or produce meaningful language

Differences between left side and right side of the brain

Left side of the brain

  • seems to control language, writing, logical thought, analysis, and mathematical abilities, – processes information sequentially, – can speak.

Right side of the brain

  • controls emotional expression, spatial perception, recognition of faces, patterns, melodies, and emotions,


  • processes information globally


  • cannot speak.


Split brain research

  • Study of patients with severed corpus callosum
  • Involves sending messages to only one side of the brain
  • Demonstrates right and left brain specialization

Hormones interact with nervous system and affect behavior

  • Hormones are similar in function to neurotransmitters
  • hormones can operate over a greater distance and over a much greater temporal range than neurotransmitters

different between hormone and Neurotransmitters

  • hormone have longer travel distance than Neurotransmitters
  • the degree of voluntary control that can be exerted over their functioning
  • In general, there is more voluntary control of neural than of hormonal signals. It is virtually impossible to will a change in your thyroid hormone levels, for example, whereas moving your limbs on command is easy.

Hormones coordinate the physiology and behavior of individuals by regulating, integrating, and controlling bodily functions

  • hormones have often been co-opted by the nervous system to influence behavior to ensure reproductive success.
  • For example, the same hormones, testosterone and estradiol, that cause gamete (egg or sperm) maturation also promote mating behavior.
  • Estrogens and progesterone concentrations are elevated during pregnancy, and these hormones are often involved in mediating maternal behavior in the mothers.

Study of the brain and how it works

Neuroscience Capture

Benefit: it promotes more effective and natural interaction between humans and technology

Examples of successful neuroergonomics research:

  • Neuroimaging and adaptive automation
  • Molecular genetics and proteomics

Bottom part of the brain - The inferior part of the brain is the brain stem, which consists of medulla oblongata, pons, reticular formation (RF), and cerebellum.
Capture

Medulla Oblongata

Pons

  • Location: the larger swelling superior to the medulla that connects the top of the brain to the bottom
  • Function: plays a part in sleep, dreaming, left–right body coordination, and arousal.

Reticular formation (RF)

Cerebellum

Structures that control emotion, learning, memory, motivation - The limbic system is a group of several brain structures located in the inferior aspect of the cortex.
Capture

Thalamus

  • Location: located in the center of the brain because this structure relays sensory information from the lower part of the brain to the proper areas of the cortex.
  • Function: processes some sensory information before sending it to its proper area.

Hypothalamus

  • Location: small structure in the brain located below the thalamus and directly sits above and controls the pituitary gland.
  • Function: responsible for motivational behavior such as sleep, hunger, thirst, and sex.

Hippocampus

  • Location: curved structure located within each temporal lobe.
  • Function: responsible for the formation of long-term memories and the storage of memory for location of objects.

Amygdala

  • Location: brain structure located near the hippocampus.
  • Function: responsible for fear responses and memory of fear.

References:
1) Neuroscience and Motivation: What You Need to Know | ITA Group. Itagroup.com. Retrieved 3 October 2021, from https://www.itagroup.com/insights/neuroscience-and-motivation-what-you-need-know.


2) The Brain - Structure, Function. pharmacy180.com. Retrieved 3 October 2021, from http://www.pharmacy180.com/article/the-brain-3551/.


3) The Limbic System. Webspace.ship.edu. (2009). Retrieved 3 October 2021, from http://webspace.ship.edu/cgboer/limbicsystem.html.


4) Parasuraman, R., & Rizzo, M. (Eds.). (2008). Neuroergonomics: The brain at work. Oxford University Press.

Nervous System
-An extensive network of specialized cells .
-Carry info to and from all parts of body.

Neurotransmitters

CNS

PNS Carries message to and from CNS

Brain

Autonomic nervous system Control involuntary body functions.

Somatic Nervous System Control voluntary muscles and transmit sensory info to CNS.

Spinal Cord

Parasympathetic division Relax the body to conserve and maintain energy.

Sympathetic division Stimulate body to expend energy..

  • Location: the first large swelling superior to the spinal cord, forming the most inferior part of the brain.
  • Function: responsible for life sustaining functions such as breathing, swallowing, and heart rate.
  • Location: an area of neurons running through the middle of the medulla and the pons and slightly beyond
  • Function: responsible for selective attention.
  • Location: part of the inferior aspect of the brain located behind the pons
  • Function: controls and coordinates involuntary, rapid, fine motor movement.

Purpose: it examines complex cognitive functions of humans performing real work in real settings, which are the neuroergonomics

Glutamate

Norepinephrine

GABA

Dopamine

Serotonin

Endorphins

Acetylcholine

memory & stimulates movement

mood, sleep & appetite

sleep & inhibits movement

memory formation

arousal & mood

control movement & sensation of pleasure

pain relief

Cleaning Synapse

Reuptake

Process when neurotransmitters are taken back into synaptic vesicles

Sending message to other neuron

Neuroscience
-Deals with the structure & function of neuron, nerves, nervous tissue.

Relationship to behaviour and learning

Neuron image

Receive and send messages within system

Cell that makes up the nervous system

Parts of Neuron

Dendrites Receive message from other neurons.

Soma (cell body) Maintain the life of the cell

Axon Carries message to other neurons

Synaptic Vesicle

Synapse/Synaptic Gap

Axon Terminal

Receptor sites

The round ending of axon is called Synaptic knob.

Branches at the end of axon.

Store various neurotransmitter that are released at the synapse.

Small gap between the axon terminal of the presynaptic neuron and the membrane of the postsynaptic cell.

Proteins typically found on the surface of cells, which are capable of recognizing and bonding to specific molecules.

Neuron Communication

Inhibitory neurotransmitter decrease the likelihood that the neuron will fire an action potential

Excitatory neurotransmitter increase the likelihood that the neuron will fire an action potential

Other Brain Cell

Myelin : an insulating layer, or sheath that forms around nerves , made up of protein and fatty substances

Glial Cells : non-neuronal cells in the central nervous system, does not produce electrical impulses.

Maintain homeostasis, form myelin in the peripheral nervous system, and provide support and protection for neurons

Allows electrical impulses to transmit quickly and efficiently along the nerve cells

If damaged, these impulses slow down

Generating Neural Impulse

Action Potential

Resting Potential

All-or-none

Ions: Charged particles

Outside neuron +ve charge

Inside neuron -ve charge

the imbalance of electrical charge that exists between the interior of electrically excitable neurons (nerve cells) and their surroundings.

the release of the neural impulse consisting of a reversal of the electrical charge within the axon

Allows +ve Na ions to enter the cell

Neuron either fires completely or does not fire completely

Process

  1. In resting state, axon has a -ve charge inferior.
  1. During action potential, +ve charge ion rush into axon. Changes the electrical charge inside the axon from -ve to +ve. Now, the charge outside become -ve.
  1. Action potential advances as +ve and -ve charges reverse in a moving zone of electrical activity that sweeps down the axon.
  1. After action potential, +ve ions rapidly flow out of axon to quickly restore -ve charge, returns to its resting state.

neuron (2)

neuron (1)

neuron

brain (2)

brain (1)

brainstorm

auto

automatic-flash

nerve

nerves (1)

neuron (3)

negative-ion

impulse

communication

chat

promotion (1)

difference

ways

is-not-equal-to

diagnostic

light-bulb

artificial-intelligence

process (2)

nervous-system

nervous-system (1)

spinal-cord (2)

spinal-cord (1)

spinal-cord

brain (4)

heads