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Lec 1🤩 - Coggle Diagram

- - - - Example 1: the chemical name 2-methyl-5-nitroimidazole-l-ethanol is condensed to the generic name metronidazole. The word methylnitro is condensed to metroni and dazole is due to its imidazole ring
      - Example 2: Metoclopramide is the condensed form of the word
        methoxychloroprocainamide: where Me is retained and th is written as to; chloro is written as clo: and procainamide is written as pramide
  - - - Example 1: Metrogyl® is the trade name for metronidazole.
      - Example 2: Reglan® is the trade name for metoclopramide.
      - Example 3: Amoxil® is the trade name for amoxicillin.
      - Example 4: Celebrex® is the trade name for celecoxib
- - - - e.g., α&b receptors à targets for adrenaline
      - It is deﬁned as a macromolecule or binding site located on cell surface or inside the effector cell.
        
        serves to recognize the signal molecule/drug and initiate the
        response to it.
        
        but itself has no other function e.g. G-protein coupled receptor.
      - They have speciﬁc recognition
        sites that bind selectively with a
        structurally-related group of
        synthetic drugs and endogenous
        mediators (ligands).
      - They responsible for transducing
        extracellular signals into intracellular response
    - - e.g., Na channel of excitable membranes à target for local anesthetics
    - - e.g., cyclooxygenase à target for NSAIDs (e.g., aspirin)
    - - e.g., norepinephrine carrier target for maprotiline (Tetracyclic antidepressant).
    - - DNA: antimicrobial and anti-tumor drugs interact directly with DNA
      - RNA: such as ribavirin against HCV