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STIs - Year 2 - Coggle Diagram

- - - - HSV-1
      - HSV-2 = increase risk of HIV
      - Varicella Zoster
    - - mucus membrane, abrasions at epidermis > travel through axon > dorsal root ganglion nerves > latent stage >activate by stress, fever, cold > release from neuron > epithelial cells > replication > spread
  - - - damaged skin, mucus mems > spread by lymphatics > bloodstream > CNS, any organ
  - - - Need a host* > infect by receptor-mediated endocytosis > limit lysosome fusion
- - - - Micro-organism: HIV-1, group M strain
      - Clinical: weak IS, OI
    - - Micro-organism: Herpes simplex virus (HSV)
      - Clinical: blisters>genital ulcers, advanced HIV = granulomas on genitals
    - - Clinical: warts
      - Different strains - HPV 11, 16,18
  - - - Micro-organism: Trichomonas vaginalis
      - Men: asymp
      - Women: vaginitis = milky, bubbly discharge, fishy smell; pain when urinating
      - Pathogenesis
        
        bind to epithelial cells > disrupt vaginal micro-org > IR launched > yellow, greenish discharge
      - Diagnosis
        
        Rapid antigen test, PCR
        
        Microscopy - motile trophozoites
  - - - Micro-organism: Neisseria Gonorrhea - gram neg diplococci
      - Clinical: yellow/white/beige discharge, conjunctivitis, pain on urination
      - Pathogenesis
        
        Pili > adhere to mucosa > bind to epithelial cells >IR launched > damage cells
      - Diagnosis
        
        Microscopy
        
        Pus from urethra and cervix
        
        Culture
        
        Blood culture - for dissemination
    - - Micro-organism: Chlamydia Trachomatis
      - Clinical: milky (mucopurulent) discharge
    - - Micro-organism: Treponema pallidum
      - Clinical: genital ulcers, warts, sores, rash
- - - - Allergic = doxycycline
- - - - Metronidazole (syndromic approach)