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HIV - Year 2 - Coggle Diagram

- - - - Cause: HHV-8
      - Who: immunocompromised patients
      - What: multiple reddish lesions, nodes, dissemination to visceral organs
      - Where: vascular neoplasm = mucus membranes (mouth, throat, nose), skin
  - - - "Spur him on" - Cryptosporidium, Isospora belli and microsporidium
      - Toxoplasmosis - pneumonia, encephalitis, CNS masses
    - - TB - atypical infections*
      - BCG adenitis - MTB bovis
      - Bacterial pneumonias
    - - Can - Candida - oral thrush
      - He - Histoplasmosis - pneumonia
      - Please - Pneumocystis jiroveci - pneumonia
      - Come - Cryptococcus - meningitis
    - - CMV
      - Human papovavirus (JC virus) - progressive multifocal encephalopathy
      - Herpes simplex virus - local mucocutaneous lesions/disseminated disease
- - - - Dolutegravir
        
        SE: insomnia, CNS
  - - - Atazanavir
        
        SE: unconjugated hyperbilirubinemia
      - Lopinavir, ritonavir
        
        SE: diarrhea, hypercholesterolemia, hypertriglyceridemia
  - - - Efavirenz
        
        SE: rash, hepatotoxicity
  - - - Tenofovir
        
        SE: renal dysfunction
      - Zidovudine
        
        SE: anemia
- - - - Detect viral particles
      - Use during window period = peak viral load
    - - Detect integrated viral genome in WBC
      - Infants!
      - highly sensitive
    - - Detect antibody
      - after window period
      - 4th generation ELISA = use in all stages of infection
    - - Detect antibody
  - - - indicate stage of disease
    - - Detect free virus in blood plasma
      - use for prognosis