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UTI - bacterial, acute - Coggle Diagram

- - - - adults
        
        ciprofloxacin
        
        gentamicin
        
        ceftriaxone
      - kids = ceftriaxone
  - - - Uncomplicated community-acquired
        
        Nitrofurantoin 100mg PO 6 hr for 5-7 days
        
        Fosfomycin 3g PO single dose
        
        Gentamicin - 5mg/kg IM - not use in pregnancy, kidney disease
      - Complicated community-acquired
        
        kids = amoxicillin clavulanic acid 15-25mg/kg/dose of amoxicillin component 8 hrly 7 days
        
        adults = ciprofloxacin 500mg PO 12 hrly 7 days
- - - - Virulence factors
        
        Capsule - phagocytosis
        
        Flagella - ascent
        
        Adhesions
        
        Pili
        
        Outer membrane proteins
        
        Fimbriae
        
        Bacterial enzymes, toxins
        
        Aerobactin - for iron uptake
        
        Urease - urea breakdown - increase pH - precipitants - crystals, stones
        
        Hemolysins, cytotoxins - damage host
- - - - Epithelial cells (squamous)
        
        contamination
      - Leucocytes - WBC
        
        Inflammation
        
        Neoplasms
        
        Kidney stones
      - Hematuria
        
        Hemorrhagic cystitis
    - - Leucocytes - WBC
      - Hematuria
      - Nitrites - bacterial presence
      - Proteinuria
    - - Mixed growth
      - Pure growth