Anatomical Pathology

Immune mediated Glomerular disease

Immune complex disease-granular deposits

Anti-BM disease

Circulating immune complex(>deposited in the glomerulus(Ag/Ab)>activate complement.>↑ in inflammatory cells

Foreign antigens deposited in BM to which Ab are attached>>complement activation

Has linear deposits due to antibodies specific against the BM

Spectrum

Post-streptococcal glomerulonephritis-antigen complex stuck underneath the endothelium>complement cascade activated>lots of cells come into glomerulus>release enzymes>damages endothelium cells>cause endothelial cell proliferation>BM damaged>Present with Hematuria

IgA nephropathy>Deposits in the mesongium

Membranous Nephropathy(Nephrotic): Antigens stuck underneath podocytes>podocytes damaged>foot processes destroyed>leakage of proteins into urinary space

SLE-Overlap

Glomerulonephritis-macro

CRF-ongoing process= fibrosis >cause fibrosis>kidney small & has granules

ARF>Large(LOTS of blood volume into kidney-not filtered), Pale(cortex-endothelial cells damaged>swell & proliferate>blockage of blood into glomeruli), edematous(↑ Hydrostatic pressure)

Micro

Tubules=Nephritic: Red cell casts, Nephrotic-protein casts

Interstitium-oedematous(

Glomeruli-changes in cellular composition & BM , Immunolabelling=IgG and/or granular deposits

Blood vessels>Hypertensive changes (late stages)