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The Pathology of Pain - Coggle Diagram
The Pathology of Pain
Main Sections
Anatomy of Primary Somatosensory Neurons Relevant to Neuropathic Pain
Peripheral Nerves
"1st responders"
"reflex withdrawal"
"pain can be a result from damage to diameter nociceptive neurons"
long inhabitance to axons = same potential damage as removing axon from cell body
Cutaneous Sensory Receptors
Very specific responses for each receptors.
Autonomic Neurons
resonses: sweating / nausea
can feel 'pain' in different location than 'issue' is originating
Dorsal Root Ganglia
"localization of various neurotransmitters or surface antigens" - fact check resource
located: each exiting spinal nerve
location of cell bodies
Pathology of Neuropathic Pain
Nerve Injury
Peripheral Effects
Wallerian degeneration - study
Some non-neuronal cells can damage axons and myelin if activated
Effects on Dorsal Root Ganglia
Entire neuron can suffer/terminate if cell body or close to cell body damaged
Autonomic Effects
intermix with sensory & motor, tend to get injured and or damaged easily because of overlap and location
Central Effects
phantom limb pain as well as dark neurons
Regenerating Axon Sprouts and Neuroma Formation
skin unervation
A neuroma is a tangled mass of axons. They are usually thinner, have less or no myelin, are shorter than original myelin internodes, and are more electrically excitable
Degeneration of Primary Afferent Neuron in Shingles & Postherpetic Neuralgia
Shingles
severe damage to primary sensory neuron
"affects only a single sensory ganglion & nerves & tracts it creates"
Primary Central Pain Syndrome - Damage to CNS Neurons
location of lesion determines whether pain will be produced
Nosology of Pain
Three main types:
Acute Pain
Chronic Pain
Nociceptive Pain
Neuropathic Pain
Pathological Pain
Spontaneous vs. Evoked (via stimuli) Pain
ABSTRACT
General background to neurons / classifications
author wants to inspire individuals to further research in area
CONCLUSION
author stresses this topic is given less importance as it is difficult to study