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Pharmacology: Drugs & Kidneys - Coggle Diagram
Pharmacology: Drugs & Kidneys
Drug elimination 1
Drug/active metabolite=accumulate in renal failure>>toxicity , e.g Aminoglycosides
Kidney=commonest eliminator of drugs
Drug Elimination 2
3 processes
:GFR ,Passive Tubular Reabsorption & Active Tubular Secretion
Total Renal Elimination=(Filtration+ Secretion)-Reabsorption
Renal Metabolism
Vit D
activated in kudneys>>In chRF>>active form is given because diet Vit is not properly actigavted
Kidneys produce
erythropoietin
>Anemia controlled by exogenous
erythropoietin administration
Insulin
metabolised by kidneys>↓ dose in diabetics with RF
Prescribing in RF 1
↓ dose /↑ dose interval ,
except
: ↑ dose in loop diuretics
Estimate creatinine clearance/GFR
Check appropriateness of drug use/need for dose adjustment
Renal dosing tables
based on stable chronic kidney disease
Prescribing
Caution with drugs that ↑ K+(ACE inhibitors, spironolactone)
Measure[Drugs]
Avoid nephrotoxic drugs
Most drugs=cleared by dialysis