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recognition of autoantigens, Cynovial, activation and migration of CC4…
recognition of autoantigens
Ag uptake and process by APCs
migration to lymph nodes(Germinal center)
Ag presentation
dampening
T regulatory
TGF-beta
Th3-tTreg
Th2
IL10/4
anergy and apoptosis
Regulatory B cells
Tregitope(IVIG)
Neutrophil and MQ type 2
Cynovial
Neu
ROS production
proteases
MQ
TNF-alfa,IL1,6
INFLAMMATION
Chondrocytes/fibroblasts
RANKL release
Bone emission
osteoclasts
proliferation
proteases
cartilage damage
plasma cells
Auto Abs
activation and migration of CC4 and B cells to cynovial
plasma cells
AUTO Abs
IgM
IgG
Anti-citrulating Pro(Fibrin-Fibronectine)
formation of TH1 /TH17
promoting inflammation
IL-17
Promoting MQ to produce inflammatory cyt
Immune complex and complement activation