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RENAL PHYSIOLOGY 3 - Coggle Diagram
RENAL PHYSIOLOGY 3
Urea Handling
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Urea impermeable in the medullary , cortical CT>not reabsorbed , Urea permeable in the presence of a ADH
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Urea in the interstitial increases>urea can play role in the H20 Reabsorption , there's high osmolality due to countercurrent system
Creatinine Handling
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Index of glomerular filtrate Rate>100% Filtered , not Reabsorbed >thus excreted
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Bicarbonate
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H2O able to bind CO2(Volatile acid)>>carbonic acid(enhanced by carbonic anhydrase[Respiratory Elimination]
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Acid-Base
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Reason for H+ Regulation>>pH alters enzymatic activity(optimal=7.4-physiologic) , pH can alter drug activity=degree of ionized vs unionized portions , bioavailability & protein binding , Drug metabolism & excretion
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Buffer Systems
Buffer eg>>carbonic acid/bicarbonate, phosphate,protein(Hb) , ammonia(alkaline buffer system)
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Systems able to bind H+>resist pH changes(add acid/base),consists of weak acid & conjugate base
Metabolic Waste Products
Proteins/Purines>Creatinine , ammonia=urea, uric acid
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