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Renal Physiology 2 cntd - Coggle Diagram
Renal Physiology 2 cntd
Glucose Reabsorption
Most Glucose reabsorbed in the PCT, 98%-1st part of PCT(SGT/GLUT2), 2%-Middle/distal part of PCT(SGT/GLUT 1)
Through Sodium dependent glucose transporter in the apical side , once glucose enters>accumulates and forms gradient that can allow the glucose to move into the interstitial fluid via the glucose transporter
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Glucose not expected to be found in urine, unless excess glucose or renal threshold(transport max) is exceeded , eg pregnancy
Na+ Reabsorption(PT)
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PCT(65%) >Occurs together with other chemicals. Can carry glucose, phosphate , AA or H+ exchange
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Promotes reabsorption of other substances>H20 follows Na absorption in the PT through aquaporin-1(both apical & basal)
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Na+ & Diuretics
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DT>Inhibit Na+/Cl carrier> by thiazides, e,g (Hydrochloric Thiazides)>>K+ loss>Na+ reabsorption in the CT
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CT:Aldosterone antagonists(K+-Sparing) , eg spironolactone
Loop: Inhibit loop reabsorption>block Na+/K+ transporter>.loss of K+ , eg Frusemide
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