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Renal Physiology 2 - Coggle Diagram
Renal Physiology 2
GFR
NFP: Forward forces which favor filtration>>Capillary Hydrostatic pressure & Bowman oncotic pressure
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Determined by Net Filtration Pressure & the type of pores in the filtration network(ultrafiltration coefficient>>Measure of what can be passed through)
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Transcellular Mechanisms
ATPase: move itself from the cell to tubular lumen(Secretion via 1º transport>energy needed to move substance(H+ ATPase)
Substance move across Electrochemical gradient via an ions- Epithelial channels>Na+ , Mg2+,k+ , Ca2+)
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2ndary Co-transport in same direction(glucose & AA) into cell , facilitated diffusion(from tubular cell to interstitial fluid)
Glomerular Filtration
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Openings in filtration barrier determines what can be filtered> gives an idea of the filtration rate
Occurs in the glomerular ducts-made up of glomerular vessels & capsular cells(podocytes) which wrap around the glomerular vessels in such a way that the foot processes of podocytes, slit diaphragm, fenestrated endothelial & glomerular basement membrane=FILTRATION BARRIER
GFR Measurement
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Renal clearance of suitable substance>don't interfere with renal function ,Metabolic inert, filtered by kidneys, not secreted, not reabsorbed
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