Please enable JavaScript.

Coggle requires JavaScript to display documents.

Common lymphoid progenitor cells (CLP), CD4+ T-cells, Common Myeloid…

- - - - preDC
        
        cDC2
        
        Function
        
        Fighting wound infection
        
        Production of IL-12, IL-6, TNF and chemokines
        
        Differential transcription factors
        
        ID2, ZEB2, IRF4, Notch2/KLF4
        
        cDC1
        
        Function
        
        High intrinsic capacity to cross-present antigens via MHC class 1 to activate CD8+ T cells and to promote T helper cell type 1 and natrual killer responses through IL-12
        
        Differential transcription factors
        
        ID2, IRF8, BATF3
      - Plasmacytoid DCs
        
        Function
        
        Present in blood and lymphoid tissue
        
        Produces type 1 IFN in response to detection of viral infection through TLR
        
        Transcription factors
        
        IRF4, IRF8, E2-2, ZEB2