interactions: ASA/LMWH/SSRIs (additive GI toxicity and increased risk of bleeding), ACEIs/ARBs/BBs/loop diuretics/thiazide diuretics (decreased diuretic and anti-HTN efficacy via decreased renal prostaglandin production), cyclosporine/tacrolimus/lithium (increased risk of cyclosporine, lithium toxicity, unknown mechanism), ketorolac/pentoxifylline (additive GI toxicity and increased risk of bleeding), pemetrexed (decreased renal clearance and increased toxicity of pemetrexed), sulfonylureas (increased risk of hypoglycemia via inhibition of sulfonylurea metabolism), warfarin (competitive metabolism)