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IEL - Coggle Diagram

- - - - TCRαβ+ IEL
        
        TCRαβ+CD8αα+ IEL
        
        heterogeneous population of
        cells with diverse MHC class I restriction
        
        develop in cryptopatches
        
        TGF-B play arole in CD8aa expression
        
        influenced homeostasis by microbiota
        
        NOD2
        
        Vit D
        
        enriched with LAG3,TGF-B3,FgL-2
        
        immunity against colitis by IL10
      - TCRγδ+ IEL
        
        10–15% of all IEL are TCRγδ+ cells
        
        MOST Vγ7 and some express Vγ1 or Vγ4
        
        extrathymic origin
        
        development dependent on BTLN rather food or microbiota
        
        expression
        
        IFN-γ, TNF-α,
        
        TGF-β, IL-10, and IL-13, prothymosin β4, keratinocyte growth factor (KGF), and antimicrobial proteins
        
        migration
        
        homotypic
        interactions mediated by the tight-junction protein occludin
        
        express antimicrobial effectors
        
        MYD88 mediated
        
        inhibit activation of other immune cells
  - - - CD2, CD5,
        CD28, LFA-1 and Thy1
    - - CD4
        
        largest T cell subset in peripheral lymphoid organs, are also found in the IEL compartment.
        
        SOME
        
        migrate into the intestinal epithelium where they can respond to subsequent antigenic challenges as bona fide effector or tissue-resident memory T cells
        
        TCRαβ+CD4+CD8αα+ IEL
        
        human intestinal epithelium
        
        regulation by microbiota
        
        cytolytic activity-granzyme expression
        
        regulatory function
        
        IL10 production
        
        TCRαβ
        +CD4+CD8αα+Foxp3− phenotype
        
        by FOXP3 T reg
      - CD8
        
        TCRαβ+CD8αβ+
        
        70-80% of the total IEL
        
        effector or memory cells
        
        granzyme B, CD69, CD103 and β7 integrin.
        
        lower amounts of TNF-α and IFN-γ.
        
        some express CD8αα
        
        express inhibitory and co-activating NK cell receptors
        
        implicated in ciliac
- - - - a subset intraepithelial
        NKp46−Ly49E+ cells
        
        producing IFN-γ in response to IL-12, IL-15, or IL-18
  - - - requires IL-15,
      - the transcription factor Notch1, the Cd8α enhancer E8I
      - the thymus leukemia (TL)antigen,
      - a non-classical MHC class I molecule expressed by IEC that serves as a highaffinity ligand for CD8 (Box 1). T-bet and other transcription factors such as Id2, Ahr and
      - RORγt are dispensable for their development
    - - production of the cytokines monocyte chemotactic protein-1
        (MCP-1), IFN-γ and osteopontin, and cytotoxic and phagocytic activities