Please enable JavaScript.
Coggle requires JavaScript to display documents.
Innate lymphoid cells, ɣδ T cells, Epithelial cells, Intraepithelial…
Innate lymphoid cells
Function: Key role in mucosal immunity and homeostasis. They help to induce an appropriate immune response to the microbiome at homeostasis. In healthy people, the mucosal immune system works symbiotically with organisms that make up the microbiota.
-
-
ɣδ T cells
• Unique T cell subpopulation that are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as skin, intestines and lungs. Suggested thqat yG T cells may expand the spatial immune responsiveness to anatomical sites that are not well served by abT cells or B cells
Function: Production of large amounts of cytokines namely IFN-g and iL-17
IFNy producing -- surface markers CD27, CD45RB
IL-17 producing -- lack Cd27,
Location: dermis,bones (prevention bone loess by tissue repair through production of amphireguln and IL-17)
Epithelial cells produce IL-7 and IL-15, IGF1 --> promote DETC proliferation in the epidermis -> on tissue damage, DETCs retract their dendrites and round up.
Bacteria causes Vy4 yGT cells to produce IL-17 and AMPs (antimicrobial peptides), while having no apparant impact on their homeostasis
Cells they influence: Bones, thermogenesis, synaptic plasticity, wound healing, tissue repair - How: secretion IL-17, result of their influence (zie hierboven)
Epithelial cells
-
-
Alveolar epithelium: : Type I and II pneumocytes AECs express a similar variety of PRRs as IECs including all known human TLRs, RIG-1-like receptors, NOD-like receptors, C-type lectins and surfactant protein
-
-
-
-
-
-
-
-
-