Please enable JavaScript.
Coggle requires JavaScript to display documents.
Immunology: Helminth infections - Coggle Diagram
Immunology: Helminth infections
Immune response
Th2 effector cells
IL-4
AAM
B cells =
IgE
ADCC = opsonization for ADCC
IL-5
Eosinophils
Receptor: Fc-ipsilon receptor
ECP, EDN, EPO, MBP
ADCC
IL-3, IL-9
Mast cell recruitment
IL-13
Epithelial repair, mucus (goblet cells)
AAM
Th1 effector cells
Activate macrophages
tissue damage and tissue remodeling
Nitric oxide = lysis of helminth
ADCC
B cell activation = IgG2a
Innate immunity = expel parasite and tissue healing
Barrier damage
Alarmins: IL-25, IL-33, TSLP
activate ILC2s, mast cells, basophils, neutrophils, dendritic cells
Th2
!!!!
DC = APCs = parasite expulsion
Neutrophils = Hydrogen peroxide
ADCC
hematopoietic stem/progenitor cells - MPP type 2
INFLAMMATION!
IL4, 5, 13
Host-protective responses = polarization of M2 macrophages and recruit eosinophils
Expel parasite
tissue healing
Soil transmission
Modified direct
Eggs in stool - into soil - undergo stages of development in soil
Penetration of the skin
Reach circulation and lungs - resp. tract - re-swallowed - intestines
Direct
Not require soil for further development
Systemic impact of intestinal helminth infection
trigger type 2 innate IR
DC
to lymphatics to mLN
promote Th2 differentiation
ES products
circulation
increase Th2 cells in liver, spleen, peritoneum