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PHARMACOLOGY, U.TABATA - Coggle Diagram
PHARMACOLOGY
Drug metabolism
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Pro-drugs(prednisone,enalapril) inactive in the form they are administered > need to be metabolized to be activated
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Prescription in Liver D.
Principles: Drugs metabolized by liver=prolongation of their half live>leads to toxicity , thus select a drug that does not go through hepatic metabolism , or select drug metabolized by conjugation(less affected by liver disease)rather than CYP450(e.g benzidine class)
Reduce drugs that undergo extensive 1st pass, liver disease=higher risk of
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Measure [drug] , use drug info sources
1st Pass Effect
drugs with ↑ 1st pass effect need ↑ oral dose than parental doses(drugs given by injection or infusion) to achieve the same effect
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Standard dose=toxic concentrations in portal hypertension > drug reaches the systemic circulation due to bypassed & diseased liver
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