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Immune-inflamed TME - Coggle Diagram
Immune-inflamed TME
Metabolism
IDO
LDH
Glucose utilazation
pathways
AMPK
mTOR
Hypoxia and HIF1-a
Immune-supressive cells
MDSC
Treg
TAM
CAF
Immue exclusion
Wnt / β-catenin pathway
TGFb
EMT
ECM
Tumor immunogenicity
Cancer-testis antigens
Neoantigen
Mutation burden
T cell immunity
infiltration of CD8 T cell
TCR signaling
total T cells
Antigen presentation
APM
Activity of DC
Infiltration of DC
Genenral Immune Status
Leukocyte Fraction
Innate immune cells
NK cell
neutrophils
B cell
Priming and activation
Co-stimulatory
M1 Macrophage
Killing of cancer cells
IFN-signaling
Cytolytic activity
Inhibitory molecules (IL-10, IL-6, VEGF)
checkpoints