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LIVER PATHOLOGY, U.Tabata - Coggle Diagram
LIVER PATHOLOGY
Cirrhosis
Morphology:Micronodular(small & firm liver with uniform nodularity , nodules(1-5mm) surrounded by fibrous septa) VS Macronodular-irregular liver>small & large nodules(portal tracks + fibrous septa)
Aetiology: Alcohol abuse, viral hepatitis, AIH, 1º & 2º biliary cirrhosis, genetic diseases, cryptogenic
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Microscopy >loss of lobular architecture, haphazard sinusoidal pattern & no central vein , portal triads replaced by fibrous tissue
Complications: Liver failure, portal hypertension , HCC
Viral hep.
Clinical: Asymptomatic acute(pt. well , serology(+), Asymptomatic chronic(pt. is a carrier) , Acute Hep.
Microscopic of A.H: necrosis, enlarged Kupffer cells, regenerative act. port & lobular infiltrate
Epidemic=HAV , Sporadic=HBV & HDV
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Liver disease
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Aetiology classification: Viruses(HBV , HBV+HDV, HCV), AIH ,Drugs, cryptogenic
Acute & Chronic:Due to viruses,drugs,alcohol
Liver Falure
Clinic signs: Jaundice, impaired oestrogen metabolism
Causes:Massive hep. necrosis,cirrhosis & hep. dysfunction w/out necrosis
Dangers: other organ system fail , hep.encelopathy
Port. Hyper
Patho: Fibrosis=vein blockage , Regenerative nodules=compress veins ,Arterio-venous shunts
Consequences: Ascites , Portosystemic vascular shunts,splenomegaly & Hep.encelopathy
Causes may be hepatic(cirrhosis), pre-hep(Port vein thrombo.) or post hep(cardiac failure,Bhudd chiari syndrome)
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