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MED VIROLOGY - Coggle Diagram
MED VIROLOGY
HDV
Circular RNA , no capsid, no envelop
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HDV Epidemiology
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HBV associated, same route of tasnmission(common:IVDU)
HEV
4 genotypes(1&2=human viruses via contaminated H20 , 3&4=Pig)
Small , non-enveloped(makes it more stable>spreads well in H20 & stool)
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HEV Epidemiology
Developing countries:similar to HAV , faecal--oral transmission,H2O-Borne
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Diagnosis
General:Transaminases , LFT
Serology-ELISA(IgM:Recent infection ,PCR
Clinical
Acute infection: Asymptomatic, Incubation:45 days, self-limiting , 10%-fulminant hepatitis , 20%-Pregnant women
Chronic infection: pig virus , similar to HCV, Limited to immunocompromised pts. , ↑ ALT & AST, Long term: cirrhosis
Clinical
Incubation:35 days, worsens HBV ourse , 30% develop fulminant hepatitis ,HBV alone:20-30%(Cirrhosis) , HBV+HDV:70-80%(Cirrhosis)
Treatment: mainly supportive , Prevention: HBV Prevention
Treatment:Acute(supportive ,ribavirin in worst cases) , Chronic:IFN-a & ribavirin