Please enable JavaScript.
Coggle requires JavaScript to display documents.
CNS, Opioids analgesics &, Anaesthesia are missing, and…
CNS
Antiparkisons
Drug induced
Antipsychotics
Reserpine
Dopaminergic
L-dopa
Carbidopa
Fluctuations
Tolerance
GI effects
On-off dyskinesia
Agonists
Pramipexole
GI effects
Mental disturbance
ulcer
MI contraindication
Apomorphine
Ropnirole
Bromocriptine
refractory to L-dopa
GI effects
obsolete
MAOi
Selegiline
Adjunctive
Insomnia
Serotonin syndrome with SSRI
Mood changes
COMTi
Entacapone/Tolcapone
L-dopa adjustment
Orange discoloration
LFT
Amantadine
Uses
Toxicity
Psychosis
Livedo reticularis
Peripheral edema
M-antagonists
Benztropine/Orphenadrine
EPS
Adjunctive
Atropine like effects
DI Parkinsons treatment
Tremors
Proranolol
Metoprolol
Huntington & Tourette
Amine depleting
Reserpine
Dopamine antagonist
Haloperidol
Wilson
Pencillamine
Restlessness
Pramipexole
Ropinirole
SM relaxants
Nondepolarizing
Atracurarium
Laudanosine
Cisatracurarium
MOA
Depolarising
Succinylcholine
MOA
Reversal of blockade
Sugammadex
Cholineesterase inhibitors
Toxicity
Resp. paralysis
ANS effects
Histamine release
Succinulcholine
Muscle pain post op
Hyperkalemia
Aspiration chances
Malignant hyperthermia
Trismus
Interaction
Aminoglycosides
Antiarrythmic
Aging
Myasthenia patients
Spasmolytic drugs
Diazepam
Dantrolene
Gabapentin
Botulinum Toxin
Antidepressants
TCAs
First pass metabolism
inhibit reuptake transporters
Toxicity
M-blocker
CV effects
Sedation
Weight gain
3 Cs
Uses
Plenty before
Now
Enuresis
Neuropathic pain
SSRI
Names
SERT
Uses
CNS stimulation
Seizures
OCD
GAD
PTSD
Dysphoric disorder
Problems
Sexual dysfunction
EPS
QTp
Serotonin syndrome
MAOi
Heterocyclic
Ketamine
Sedatives & Hypnotics
MOA
BZ
GABA
Inc. frequency of Cl- opening
Flumazenil antagonism
Curve flattens out
Barbiturates
GABA
Inc. duration of Cl- opening
Block glutamic acid
Z-drugs
GABA
Selective
Flumazenil antagonism
Actions
Sedation
Hypnosis
Z-drugs better
Anaesthesia
Midazolam
Thiopental
Anticonvulsants
Lorazepam
Status epilepticus
Muscle relaxation
Diazepam
Spastic state
Cerebral palsy
Medullary depression
Tolerance
Dependence
Abstinence syndrome
Newer drugs less
Toxicity
Psychomotor dysfunction
Long HL BZ
Beers criteria
Anterograde amnesia
BZ
Date rape
Z-drugs
Sleep driving
Overdose
CVS & Resp. depression
Alc, Barb > BZ > Z-drugs
Management
ABC
Ventilation
CNS depression
drug interactions
Others
Barbiturates
CYP450
Warfarin displacement
Acute intermittent porphyria
Misc
Buspirone
Selective anxiolytic
5HT1 partial agonist
Slow
No withdrawal/abuse
Tasimelteon
Melatonin agonists
Suvorexant
Orexin antagonist
Alcohols
Ethanol
Alcohol dehydrogenase
Fomepizole
Zero order
MEOS
hepatotoxicity
Ald. Dehydrogenase
Disulfiram
Metronidazole
metallic taste
Cephalosporins
Chlorpropamide
Griseofulvin
Asians genetically low
Acute effects
CNS depression
Ataxia
Slurred speech
Drunk driving
Tolerance
Heart depression
Hypothermia
Chronic effects
Alcoholism
Alc. steatosis
predisposition
HBC/HCV
GI
inflammation
absorption problems
pancreatitis
Neurologic
Per. neuropathy
Wernicke Korsakoff
Thiamine and then glucose
to make sure glucose is utilised
ER
Endocrine
Altered steroid metabolism
CVS
HTN
Anemia
Dilated cardiomyopathy
Arrythmia
Neoplasia
Immunity
Disposition to infectious pneumonia
Alcohol withdrawal syndrome
Delirium Tremens
Thiamine
Electrolyte balance
BZ
Diazepam
Misc
Methanol
Visual damage
IV ethanol for treatment
Ethylene glycol
Antifreeze
Nephrotoxicity
Anticonvulsants
Pharmacokinetics
Phenytoin
First pass metabolism
Competes for binding
Sulfonamides
Carbamazepine
Valproic acid
Hepatic excretion
Induction
Carbamazepine
Binding site compete
Inc. clearance
Valproic acid
Competes for site
Hepatotoxicity
Others
Renal elimination
No drug interaction
MOA
Na+ blockers
Phenytoin
Carbamazepine
Lamotrigine
Phenobarbital
Valproic acid
GABA
BZ
Phenobarbital
Gabapentic
Felbamate
Valproic acid
Ca2+ blocker
Ethosuximide
Valproic acid
Gabapentin
Misc like NMDA & K+
Valproic acid
Phenobarbital
Felbamate
Uses
GTC
Valproic acid
Carbamazepine
Phenytoin
Alternative
Phenobarbital
Lamotrigine
Partial seizures
Carbamazepine
Lamotrigine
Phenytoin
Alternative
Felbamate
Phenobarbital
Valproic acid
Adjunctive
Gabapentin
Absence
Ethosuximide
Valproic acid
Alternative
Clonazepam
Myoclonic & Atypical
Valproic acid
Adjunctive
Lamotrigine
Toxic
Clonazepam alt
Felbamate adj
Status Epilepticus
IV Diazepam
Lorazepam chronically
Followed by IV phenytoin
Phenobarbital
children
Others
BPD
Valproic acid
Carbamazepine
Lamotrigine
Trigeminal neuralgia
Carbamazepine
Neuropathic pain
Gabapentin
Migraine
Phenytoin
Toxicity
Neural tube defects
Valproic acid
Craniofacial anomaly + spina bifida
Carbamazepine
Fetal hydantoin syndrome
Phenytoin
Resp. CNS depression
SJ syndrome
Lamotrigine
Aplastic anemia
Felbamate
Easier withdrawal
Antipsychotics
Classification
Receptors
Pathways
Uses
Schizophrenia
Clozapine for resistant cases
Typical have no effect on negative symptoms
Mania
Bipolar depression
Antiemetic
Thioridazone
Antipruritic
Toxicity
Parkinson-like symptoms
Haloperidol
Tardive dyskinesia
Valbenazine treatment
Dont use M-blockers
ANS effects
Thioridazone > Haloperidol
Atropine like effects
Failure to ejac
Orthostatic hypotension
Neuroleptic malignant syndrome
Sedation
Chlorpromazine > Haloperidol/Fluphenazine
Endocrine
Prolactin ^
Gynecomastia
Galactorrhea-Amenorrhea syndrome
Diabetogenic
Retinal deposits
Thioridazone
QT prolongation
Agranulocytosis
Clozapine
Lithium
Pharmacokinetics
Thiazides
NSAIDs
ACE + Caffeine
Theophylline
Uses
BPD
Maintenance therapy
BZ to initiate as Tx is slow
Toxicity
Tremor
Sedation
Ataxia
Thyroid enlargement
Hypothyroidism
(N) DI
corrected with amiloride
Edema
Acneiform skin
Leukocytosis
Ebsteins anomaly
heart
Dec. Apgar score
Opioids analgesics &
Anaesthesia are missing
and Antidepressants
could use some work